Anti-aging vitamins have the potential to transform your life. NAD+ boosters are a relatively new form of anti-aging supplement that is gaining traction. Supplements containing nicotinamide adenine dinucleotide (NAD) target aging at the cellular level, resulting in significant anti-aging effects throughout the body. NAD+ boosters are also known as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) supplements and may be found at most major retailers.
What are NAD+ boosters, and how do they work? In 2021, what are the most excellent NAD+ supplements? How do you tell the difference between hype and science? Continue reading to learn everything there is to know about the top NAD+ and NR anti-aging supplements on the market in 2021.
Top NAD+ Supplements for 2021
Our editorial staff reached out to manufacturers, reviewed lab data, and personally evaluated the top NAD+ boosters on the market today. For the year 2021, we’ve ranked the top NAD+ supplements. These NAD+ boosters can help you choose one according to your needs and affordability to reverse your aging process.
Cymbiotika NMN
This popular and well-known NAD+ booster product available today is Cymbiotika’s NMN. Cymbiotika NMN, which costs less than $80 a bottle, provides your body with nicotinamide mononucleotide (NMN), the direct precursor of NAD+ and a key component for increasing NAD+ levels. Cymbiotika NMN capsules include NMN and other ingredients such as apigenin, green tea extract, resveratrol, and green coffee bean. Cymbiotika NMN may stimulate NAD+ levels in the body by providing antioxidants, polyphenols, minerals, and precursors. To enhance energy rejuvenation, anti-aging, healthy DNA protection, cognitive health, and other impacts, Cymbiotika advises taking two capsules daily.
Elysium
One of the forerunners of the NAD+ booster space was Elysium. The supplement contains an Oxford-patented scientifically validated B-vitamin combination that helps to prevent brain shrinkage as you age. The B-vitamin complex reduced age-related grey matter shrinkage in learning and memory areas by 86 percent in one research.
Elysium also includes omega-3 fatty acids, anthocyanins, and antioxidants with improved bioavailability, in addition to the unique B vitamin complex. Elysium also offers a biological age test kit for testing the supplement’s effects. Take Elysium regularly, then use the kit to determine your age before and after taking the supplement. Elysium has anti-aging properties and can help you turn back the hands of time.
Elysium provides two NAD+ supplements: Matter (for long-term brain health) and Basis (for short-term brain health) (for general anti-aging and DNA health). Elysium is also one of the few NAD+ booster products on the market that has been proven in human clinical studies.
Tru Niagen
Tru Niagen is one of our very well-known NAD+ boosters, and for a good reason. The supplement uses 500mg of Niagen nicotinamide riboside (NR) per capsule to assist drive cellular energy production and support cellular repair. According to research using 100mg, 300mg, and 1,000mg daily dosages of Niagen NR, taking one capsule of Tru Niagen daily may reportedly raise NAD+ by 80%.
Tru Niagen is available in 300mg and 500mg doses. Many people use Tru Niagen regularly to help with cellular vitality, aging, and general health and wellbeing. Tru Niagen is also available in 30 count, 90 count, and 180 count bottles. You save more money the more you buy. Tru Niagen is one of the NAD+ supplements on our list since it is one of the few backed by scientific data.
RiboGEN
RiboGEN is a nicotinamide riboside (NR) supplement with 300 mg per serving. RiboGEN’s creators claim that their supplement is the only pharmaceutical-grade supplement that employs the same purity of NR utilized in medical research and clinical trials.
The NR in RiboGEN works in the same way that the NR in the other NAD+ supplements described here does: it acts as a precursor to NAD synthesis, providing your body with the components it needs to create NAD and therefore increasing NAD+ levels. RiboGEN is a no-nonsense NR supplement with a concentration of 99.5 percent nicotinamide riboside and 0.5 percent NAM related to putative NAD+ enhancing effects.
RiboGEN appears to be more expensive than the other NAD+ boosters on this list, at $330 a bottle. However, because each bottle includes 300 capsules (300 doses), RiboGEN is more expensive than the other supplements on this list.
Science.bio NR Chloride Powder
One of the most effective nicotinamide riboside (NR) supplements available is from Science.bio. Under $30 for 10g jars of Science.bio’s NR Chloride Powder. To take advantage of the potential NAD+ boosting advantages, mix the powder as needed, or put it in your capsule.
To assure quality and transparency, each batch of Science.bio’s NR Chloride Powder is batch and lot-coded, with publicly viewable lab records. The jar is also UV-protected to prevent it from deteriorating. That means you’ll get the most significant dose of nicotinamide riboside possible, with none of the filler chemicals seen in other NAD+ booster formulations on the market today.
Life Extension NAD+ Cell Regenerator
The name of Life Extension’s supplement tells you precisely what it’s supposed to do: it’s designed to renew cells by increasing NAD+ synthesis. Life Extension NAD+ Cell Regenerator contains a 300mg dose of Niagen NR, just like the other NAD+ boosters listed here. To augment the effects, even more, Life Extension has added trans-resveratrol to every dose, resulting in increased NAD+ levels.
NAD+ Cell Regenerator can help battle weariness on a cellular level, enhance mitochondrial health, and maintain young cellular energy production, among other things, according to Life Extension. At $45 per bottle, it’s one of the more cost-effective NAD+ boosters on the market, with chemicals similar to those found in other NAD+ boosters but at a lower price.
Quicksilver Scientific Liposomal NAD+ Gold
NAD+ Gold is a popular NAD+ booster supplement from Quicksilver Scientific. The supplement claims to increase NAD levels, which will lead to better aging, cognition, and vitality. Quicksilver Scientific’s NAD+ Gold, like the Alive By Science NAD+ boosters above, uses liposomal delivery for improved bioavailability, which means more active chemicals end up in your bloodstream.
Simply take two pumps of NAD+ Gold and hold them in your mouth for 30 seconds. Swallow after that. NAD+ precursors (including NMN) are included in the formula, which aids in increasing NAD+ levels in the body. Quicksilver Scientific is one of the best-reviewed NAD+ booster firms on the market today, with a high-powered liquid tincture costing $60.
Toniq NMN
Toniq’s NMN has some of the most attractive bundles on the list. When dealing with a no-nonsense NMN-based NAD+ booster, you’d expect no-nonsense packaging. Each bottle includes 99 percent pure NMN, which can help your body manufacture more NAD+ by providing the precursors it needs.
Even though Toniq NMN is a high-quality NAD+ supplement with 60 servings per bottle, it is only $45 per bottle. The larger bottle with 180 pills will save you much more money. Toniq NMN is a supplement that claims to provide your body with high-quality nicotinamide mononucleotide (NMN) in each serving, assisting in NAD+ generation.
HPN Supplements NAD3 NAD+ Booster
NAD3 is an NAD+ enhancer that HPN Supplements supply. The formula is marketed as a “fountain of youth,” Each serving contains 311mg of a proprietary composition. While most NAD+ boosters rely on NR or NMN, HPN supplements have developed their exclusive combination, the NAD3 Patent-Pending Formula.
You can raise telomerase activity for aging, reduce cellular inflammation, activate NRF2 for cell detoxification, and boost NAD+ for mitochondrial function, among other things, by taking NAD3 daily. It’s also one of the more cost-effective NAD+ boosters on our list, with 60 servings for $60.
Liftmode NMN
Each bottle of Liftmode’s NMN contains 10g of nicotinamide mononucleotide. Unlike NR, NMN is not a vitamin B3 variation. Instead, it’s a synthetically manufactured nucleotide that, like NR, has been related to anti-aging effects by affecting NAD+ levels. Each jar of Liftmode NMN includes 10g of pure NMN, allowing you to tailor your dose to your preferences.
The Liftmode NMN formula, according to Liftmode, can enhance healthy cellular energy levels, produce tremendous regenerative effects, sharpen cognitive performance in the aging brain, and other benefits. In addition, Liftmode maximizes purity and potency by using a transparent, sealable plastic jar.
Alive By Science
NAD+ boosters from Alive By Science include unique liposomal gels that act differently than any other supplement on this list. NAD+ with Resveratrol LIPO Gel and NMN with Resveratrol LIPO Gel are two of Alive By Science’s most well-known products. The gels, which cost $75 to $80 a bottle, are meant to be used sublingually (under the tongue) for maximum absorption.
Powdered NMN and NAD+ supplements are also available from Alive By Science, allowing you to get the benefits of NMN and NAD+ supplementation in a convenient capsulated form. Alive By Science may offer the correct NAD+ boosters for your specific anti-aging needs with different solutions for all tastes and preferences.
Top 4 Benefits of NAD+ Boosters
For its alleged benefits, many people take NAD+ boosters daily. All of the following advantages could be supported by a strong NAD+ booster supplement:
Fights Age-Related Memory Loss
Your memory naturally deteriorates as you get older. NAD+ is required for DNA repair and neural stress resistance. Many people find that taking an NAD+ booster improves their memory and recall.
Minimizes aging effects
Many people take NAD+ boosters to slow down the aging process. While NAD+ boosters won’t make you instantly younger, research shows that they may assist your body cope with the impacts of aging. Researchers gave mice NAD+ boosts in one trial, for example. Researchers couldn’t tell the difference between tissues taken from four-month-old mice and tissues taken from two-year-old mice who had received the NAD+ booster after one week. In other words, the NAD+ booster appeared to slow down the aging process.
Reduce Weight
NAD+ boosters have been shown in studies to help counteract the effects of high-fat diets and make weight management easier. In one study, mice on a high-fat diet who were given an NR supplement acquired 60% less weight than those given a placebo. These mice were also more energetic.
Enhances bodily strength
Some people use NAD+ boosters to improve their athletic performance. NAD+ boosters have been shown in studies to improve muscle strength, endurance, and other benefits. NAD+ boosters have been related to DNA repair, muscle growth, and increased endurance at the cellular level, among other things.
How We Ranked the Top NAD+ Supplements
Every NAD+ supplement claims to increase NAD+ levels while also providing anti-aging benefits. Only the best supplements, however, live up to the hype.
We utilized the following ranking variables to distinguish between the best and worst NAD+ boosters on the market today:
Proven efficacious Ingredients
NR and NMN are the two most effective substances for increasing NAD+ levels. These two chemicals are found in all of the top-rated NAD+ boosters. They are both precursors of NAD+ synthesis. The higher we ranked an NAD+ booster, the more clinically established components it contained.
Dosage Strength
The correct elements may be present in NAD+ booster pills, but the amounts are insufficient. We ensured each NAD+ booster employed effective doses of those substances after confirming they had the proper ingredients.
Ingredients’ Transparency
Some NAD+ boosters hide their ingredient labels or employ proprietary formulae, making it difficult to know exactly what’s in each bottle. We liked NAD+ boosters with clear and honest ingredient labeling that eliminated any guessing from the equation.
Complimentary Ingredients
Increasing NAD+ isn’t a precise science. Turmeric, resveratrol, and other compounds have been shown in studies to enhance NAD+ in various ways, which is why many NAD+ boosters include these ingredients. We took complementary substances into account in our rankings, but we didn’t penalize companies that didn’t have them.
Manufacturer’s Credibility
Niagen, Cymbiotika, and Elysium are three of the most well-known and well-respected NAD+ booster brands. They’ve been making high-quality NAD+ booster products for a long time. Some of the major firms have even funded human clinical trials. We picked manufacturers with a solid track record above those hoping to cash in on the NAD+ supplement craze.
Value and Pricing
Some folks are willing to invest $30 on an NAD+ booster. Others are looking to spend $200. NAD+ boosters were featured at a variety of price points. However, we placed a premium on good value at each price point to guarantee that your money was well spent on any of the top-rated NAD+ supplements listed above.
Honest Advertisement
Some NAD+ booster firms exaggerate their claims, saying that their supplement may help you lose 50 pounds in a month or reverse your age by 20 years. We were suspicious of NAD+ booster firms who advertised such benefits, and we chose companies that advertised more truthful benefits.
Human Clinical trials
Human clinical research backs some of the best NAD+ booster products on our list. Companies have put money into human trials to ensure that their supplement works as advertised—the more scientific evidence an NAD+ booster has, the better.
Top 5 Natural Ways to Boost NAD+ Levels
If you don’t want to take an NAD+ supplement to improve your NAD+ levels, you can naturally sustain healthy NAD+ levels in the body. Studies demonstrate that altering one’s food and lifestyle behavior can affect NAD+ levels.
According to science, here are five of the most effective natural strategies to increase NAD+ levels:
Reduce Calories intake
According to specific research, NAD+ production can be boosted by eating 20% to 30% fewer calories than usual.
Try out fasting
Fasting can help your body’s NAD+ levels rise. According to studies, a combination of fasting and calorie restriction can promote longevity and support healthy aging by increasing NAD+ production in the body.
Stay away from sun damage
When the sun damages your skin, your body sends NAD to help restore it. That means the NAD can’t be used anywhere else in the body. Sunscreen and protective gear can help to reduce damage and preserve NAD+.
HIIT Workout
High-intensity interval training (HIIT) has been shown in studies to increase growth hormone, NAD+ levels, and other effects. We already knew that high-intensity interval training (HIIT) could improve mitochondrial health. Still, new research reveals that these exercises can boost NAD+ levels or help your body utilize NAD+ more efficiently.
Intake of Balanced Diet
If you don’t consume enough vitamins, minerals, and nutrients, your body will struggle to make numerous essential chemicals, including NAD+. To optimize NAD+ levels and control specific aging effects, eat a healthy, balanced diet.
5 Best Food types for Boosting NAD+ Levels naturally
- Milk: Nicotinamide riboside is abundant in dairy milk (NR). A glass of milk a day may make you feel younger and healthier.
- Fish: Fish is high in precursors of NAD+; many people consume tuna, salmon, and sardines daily for anti-aging benefits.
- Mushrooms: Mushrooms can aid in the natural increase of NAD levels. You may be able to maximize anti-aging effects by including a variety of mushrooms in your diet.
- Green Vegetables: Green vegetables are high in vitamins, minerals, and nutrients that your body needs to produce NAD+ and other essential molecules.
- Yeast and Whole Grain: Vitamin B3 is abundant in whole grains, including vitamin B3 that is not found in processed grains. Similarly, nicotinamide riboside, a precursor to NAD, is found in yeast. Consider going to your local bakery the next time you need to enhance your NAD+ levels.
Side Effects of NAD+ Boosters
- NAD+ booster pills have no notable adverse effects in the majority of healthy persons.
- NAD+ boosters, like other supplements marketed online today, contain doses and components that the FDA considers to be generally recognized as safe (GRAS). When used according to the suggested dosage, these components are safe for the majority of people.
However, before using an NAD+ booster supplement or any other supplement, you should consult your doctor if you take any medications or have a medical problem.
NAD+ Booster Dosage
The majority of NAD+ boosters contain roughly 300mg of NR or a comparable amount of NMN.
The majority of research has shown that this dose can significantly increase NAD+ levels in the body. Smaller doses, as low as 100mg, have yielded similar benefits in some trials. To boost the benefits of NAD+ even more, several researchers employ dosages of 1,000mg.
To maximize NAD+ boosting benefits, search for an NAD+ booster pill containing at least 300mg of NR per serving to maximize NAD+ boosting benefits.
Scientific Evidence for NAD+ Boosters: Now aging is not an issue!
NAD+ boosters are a brand-new supplement category. However, a new study confirms key NAD+ booster benefits, and scientists believe NAD+ boosters could have substantial anti-aging effects across the body. More research, particularly large-scale human research, is needed to confirm these benefits.
In this animal study, researchers offered an NR supplement to a group of mice bred to acquire human-like age-related memory impairment. Some mice were given an NR supplement in their drinking water for three months, while others were given a placebo.
Meanwhile, in a mouse study, NAD+ boosters effectively counteract the effects of a high-fat diet. Mice were given either a high-fat diet plus an NR supplement or a placebo. Mice given the NR supplement acquired 60% less weight than mice given a placebo. Among other things, these mice had increased energy levels and enhanced oxidative metabolism.
Increasing NAD+ levels with an NR supplement may also aid with muscular function and strength. Muscle function and strength deteriorate as people age. Researchers gave mice either an NR supplement or a placebo and found that the NR group gained more strength and exercise than the placebo group. Researchers couldn’t tell the difference between two-year-old and four-month-old mouse tissues in that study, implying that NAD+ precursors (NR and NMN) could slow down the aging process.
Other research has found that boosting the activation of SIRT1, a type of sirtuins protein, promotes longevity. Researchers discovered that NR supplementation improved the longevity of mice through enhancing mitochondrial activity in this investigation on mice.
To increase NAD+ levels, you don’t need to use an NAD+ booster product. Instead, studies demonstrate that fasting, calorie restriction, and other dietary and lifestyle adjustments can considerably boost NAD+ levels.
Researchers discovered that eating 20 percent to 30 percent fewer calories than usual was linked to greater NAD+ levels in this 2014 study. Similarly, this research found that fasting and calorie restriction enhanced NAD+ levels and SIRT1 activation, possibly resulting in a longer lifetime. Many people say that keto diets and intermittent fasting regimens can increase NAD+ levels for these reasons, while further study is needed to confirm these claims.
Although many NAD+ investigations have used mice rather than humans, there have been numerous human trials. In this study, researchers discovered that NR supplementation boosted NAD+ levels in a sample of healthy adults safely and effectively. Similarly, NR supplementation dramatically increased NAD+ and adenine diphosphate ribose (AD) levels in this study published in Nature Communications.
Finally, more study is needed to prove the effects of NAD+ supplements and boosters. However, mice, animals, and humans research suggest that NAD+ boosters could be one of the most effective anti-aging treatments ever devised.
FAQs About NAD+ Boosters
Q: What is NAD?
A: NAD (nicotinamide adenine dinucleotide) is a coenzyme found in all cells. It plays a crucial role in cell metabolism. The coenzyme exists in two primary forms, including NAD+ and NADH.
Q: What’s the difference between NAD, NAD+, and NADH?
A: NAD is a coenzyme found in all cells that plays a vital role in cell metabolism. The coenzyme exists in two forms, including NAD+ (NAD that serves all functions throughout the cell) and NADH (the form occupied by electrons and unable to perform all processes throughout the cell).
Q: What does NAD+ do?
A: NAD+ plays a critical role in multiple aspects of cell metabolism, including the transformation of nutrients we eat into adenosine triphosphate (ATP), which is the fuel your cells use to exchange and produce energy.
Q: What is ATP?
A: Adenosine triphosphate (ATP) is the energy used by your cells. NAD+ helps turn the nutrients you eat into ATP, allowing your cells to exchange and produce energy.
Q: What are sirtuins?
A: Sirtuins are proteins that play a crucial role in multiple cell processes, interacting with NAD+ while playing a vital role in cellular energy. NAD+ and sirtuins help with gene expression, chromosomal maintenance, DNA repair, mitochondria preservation and stimulation, and other effects.
Q: Why does NAD drop with age?
A: Your body must continuously produce NAD to ensure cellular health and energy. However, as you get older, your body naturally produces less NAD.
Q: What are the symptoms of low NAD levels?
A: When you have low NAD levels, your cells have a reduced ability to make and use ATP energy. You could feel lethargic. You might not feel as physically or cognitively active as you used to be. NAD is crucial for cellular function and cellular energy, and you could feel complex effects at every level of your body.
Q: How does a NAD supplement help?
A: Recent studies have shown that adding NAD directly to cells can reduce specific effects of aging. Researchers have added NAD directly to cell cultures and observed mouse cells turning back the clock to resemble younger mice cells. Today, NAD supplements claim to use similar processes to reduce cellular stress, age-related stress, and cell aging.
Q: What is a NAD booster?
A: An NAD booster or NAD+ booster is a supplement that claims to target NAD within your body. As you get older, your NAD levels drop, leading to various symptoms of aging. NAD+ boosters claim to counteract these effects, restoring your body’s NAD+ levels and giving you back your cellular energy.
Q: What is nicotinamide riboside (NR)?
A: Nicotinamide riboside (NR) is one of two significant precursors to NAD biosynthesis. Studies show that your body uses NR to produce NAD+. That’s why many NR supplements are considered NAD+ boosters.
Q: What is nicotinamide mononucleotide (NMN)?
A: Nicotinamide mononucleotide (NMN) is one of two significant precursors to NAD biosynthesis. Your body uses NMN to produce NAD+, which could impact cellular energy.
Q: What’s the difference between NAD+ boosters that use NMN and NR?
A: The NAD+ supplement industry is new, and studies continue to compare NMN and NR supplements. Both NMN and NR are considered precursors to NAD synthesis within the body, which means they could raise your body’s levels of NAD (leading to higher NAD+ levels). As more research continues, we’re learning more about the difference between NR and NMN supplements.
Q: How do I increase NAD levels naturally?
A: Studies show that NAD is connected to diet and exercise habits, fat burning, and more. Diets high in fats and low in carbs, for example, may increase the ratio of NAD+ to NADH, protecting your body from oxidation and maximizing anti-aging effects. Others practice intermittent fasting to increase NAD levels naturally. Some take NAD+ supplements.
Q: Does HIIT boost NAD+?
A: Studies show that high-intensity interval training (HIIT) workouts could raise NAD+ levels. Exercising at a high level of intensity for brief periods can boost growth hormone production, NAD+ levels, and other elements linked to aging.
Q: Why can’t I just take an NAD+ supplement with NAD+?
A: NAD+ boosters contain NR or NMN, both of which are precursors to NAD+. Why? Studies show that NAD+ is too large to permeate cellular walls. You can’t just eat a spoonful of NAD+ to raise NAD+ levels. It doesn’t work that way. An NAD+ capsule would be too big to swallow, which is why all NAD+ boosters come in the form of NR and NMN supplements.
Q: Do niacin supplements boost NAD+?
A: Niacin, also known as nicotinic acid, is a type of vitamin B3 shown to increase NAD+ levels. Although it’s not been shown to be as powerful as NR or NMN, it could still raise NAD+ levels in a significant way.
Q: Is NR better than NMN for boosting NAD+?
A: Most studies on NAD+ boosters use NR instead of NMN. Some believe NMN, like NAD+, is too big for your body to absorb. The three most minor versions of vitamin B3, including niacin, nicotinamide, and NR, are the smallest precursors of NAD+ that can permeate your cell walls.
Q: What are the side effects of NAD+ boosters?
A: Most healthy adults experience no side effects from NAD+ boosters. However, NAD+ boosters with high levels of niacin can lead to reddened skin, a burning sensation, and itching in rare cases.
Q: What are the best foods for boosting NAD+?
A: Studies show that dairy milk, fish, mushrooms, and yeast can boost NAD and NAD+ levels within the body.
Q: Is sunlight harmful for NAD+ production?
A: Your body needs NAD+ to repair some of the damage done by sunlight. Excessive sunlight exposure can deplete levels of NAD+ within your body. Your body uses NAD+ to repair cells damaged by UV radiation. If you have sun damage, your body uses NAD+ to repair this damage instead of using it elsewhere.
Q: What are the benefits of NAD+ boosters?
A: NAD+ supplements claim to help restore muscle strength and stamina, boost energy levels, protect your liver, strengthen your immune system, help with sleep/wake cycles, maintain mental sharpness, and encourage DNA self-repair, among other benefits.
Q: Why are low NAD levels wrong?
A: Low NAD levels are associated with cell death, cardiovascular disease, weight gain, decreased metabolism, impaired brain function, and other effects.
Q: How does NAD IV therapy work?
A: Some people take NAD supplements to boost NAD+ levels. Others take NAD through intravenous (V) injection. Health professionals inject NAD and complementary vitamins directly into your bloodstream to deliver targeted benefits.
Q: What is the best NAD+ supplement?
A: Niagen, Elysium, and Cymbiotika are three of the best-known and best-rated NAD+ booster supplement brands available today.
Top NAD+ Supplements for 2021 Final Word
For cellular energy, nicotinamide adenine dinucleotide (NAD) is required. You may maximize NAD+ levels in the body by taking an NAD+ booster pill, which can help with cellular energy, endurance, cognition, and even weight loss, among other things.
With so many NAD+ boosters offering comparable results, it can be challenging to separate the hype from the quality. The NAD+ booster supplements mentioned above are among the best NAD+ supplements on the market today.
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Disclaimer:
Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
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