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Top 12 Best Nerve Supplements in 2021 for Nerve Pain Relief

Neuropathy is a health condition that causes the death of specific nerves in the body. It could lead to numbness, pain, weakening of muscles, or tingling in the affected areas. People develop this condition for various reasons, including genetic patterns and physical damage to the nerves. For others, it comes as the result of diabetes.

Regardless of the cause, neuropathic conditions can be minimized or eliminated by using the right supplement. However, the challenge comes when identifying the most effective neuropathy pain relief pills. Here is a list of some top, nerve-rejuvenating supplements you should consider.

Top 12 Best Nerve Supplements in 2021

Our editorial team researched and analyzed several supplements based on the manufacturers’ reputation and customer reviews to rank the best neuropathy supplements. Here are the best neuropathy supplements that we recommend for 2021 based on our findings:

  • Circle Labs CBD
  • Nerve Control 911
  • Nervogen Pro
  • Nervala
  • Nerve Rejuv
  • Nuturna Maximum Strength Neuropathy Support Formula
  • Nerve Renew
  • Nervexol
  • Neuro Calm Pro
  • Nuturna Clinical Strength Neuropathy 900
  • Bonus Nerve Pain Guide #1: Neuropathy No More
  • Bonus Nerve Pain Guide #2: Neuropathy Revolution

Circle Labs CBD


Circle Labs develops some of the best quality CBD products that could be used to supplement several health conditions, including neuropathy and diabetes. Their CBD is extracted from high-quality plants grown under ideal conditions such as clean water, natural sunlight, and nutrient-rich soil. They are made from a single type of strain from one source, carefully harvested, and handcrafted after curing. The top-level CBD flowers are chosen to ensure the CBD products are of the highest potency, containing high amounts of cannabinoids, terpenes, and flavonoids. These products are also tested by third-party labs, which have proven their mold and pesticide-free quality. They also contain less than 0.3% THC, the toxic substance that causes addiction in recreational marijuana.

Diabetes, a common cause of neuropathy, may bring along some undesired conditions such as inflammation and pain, especially to the hands and legs, which are the neuropathy-prone areas. It may also impact the immune system, compromising the body against various other health risks. There are few treatment options for neuropathy, of which CBD is one of them. Besides reviving your nervous system, it also helps control sugar levels, promote insulin production, and reduce cholesterol. Therefore it also helps to reduce diabetic symptoms.

CBD has pain-killing effects that are beneficial in curing peripheral neuropathy. Both diabetes and neuropathy cause inflammatory conditions that lead to pain in various body parts.

The human body has a natural endocannabinoid system that regulates various body functions, including pain and inflammation. When consumed, CBD binds with the cannabinoid receptors in the endocannabinoid system, present in body cells. It then promotes the endocannabinoid system in performing its regulatory functions, which eliminate most of the symptoms.

Nerve Control 911


Nerve Control is an all-natural central nervous system supplement that is exclusively sold on its official site. The PhytAge Labs product claims to suppress the constant burning and stabbing symptoms of nerve damage. The manufacturer also claims that the product improves muscle control to eliminate involuntary movements and to improve perception. The product contains a variety of ingredients in the most absorbable for immediate effects. According to the manufacturer, the blend of components in the formula also helps control insomnia, anxiety, and blood pressure. Marshmallow root and passionflower are among the most critical constituents of the formula.

According to the manufacturer, the product is entirely safe, although it is not advisable for pregnant and nursing mothers or underage. It is also advisable to consult a health professional if you have any underlying health conditions. The company utilizes UPS/FedEx and USPS services to manage a 7-business-day delivery duration. You should start to notice effects seven days after the first dosage, although the manufacturer recommends a three-month trial period of taking two capsules daily.

Nervogen Pro


Nervogen is another nervous system supplement that brings out the best results when complemented with specific lifestyle changes. According to Kevin Miller, the developer, it is an all-natural remedy manufactured in Colorado, USA. He also claims that the supplement is entirely safe, as it only comprises natural ingredients sourced worldwide. Besides, its capsules are made of vegetable matter for easy absorption by the body.

The supplier of the product recommends taking two capsules of the supplement daily. A single bottle contains 60 such capsules; hence, it should last you a whole month. Although it comprises all-natural ingredients, the supplement is not advisable for pregnant women, nursing mothers, or under-aged individuals. It is also not safe for individuals with preexisting medical conditions to consume the product without consulting a doctor. Also, the product is not safe for people who are allergic to wheat, tree nuts, peanuts, soy, milk, eggs, fish, and crustacean shellfish. If you feel unsatisfied with the product’s results before two months are over after purchase, you can request a refund. The supplier ships freely to the United States but charges an additional $15.95 for customers outside the US. Local orders take up to 7 days, while international ones can take up to 15, to be processed.



Nervala is a nerve supplement that eliminates numbness and shooting pain, according to Baton Nutrition, its manufacturer. According to the company’s description, the product works on the inside and outside of the nervous system to cool it down from being overworked, which causes pain. It also promotes protection and healing. Additionally, it utilizes two significant ingredients to suppress Oxygen-free radicals, which cause inflammation damaging body cells.

Nervala comprises two main ingredients, Alpha Lipoic Acid and Benfotiamine. ALA is a potent antioxidant component whose primary function is to suppress inflammation and the free radical attacks that damage your nervous system. It consumes the free radicals to enable your nervous system to function better. It is more effective than other such remedies as it penetrates cell membranes to stop the overworking, allowing the body to engage its self-repair mechanism.

While ALA takes control of activity in the nerve cells, Benfotiamine’s work empowers them by moderating the amount of activity they engage in to sustain their functionality. The ingredient is unique for its gradual absorption rate, ensuring the body only uses the required amounts and stores the rest for later use. The element induces a counteracting force to what diabetes does – overworking your nervous system to cause damage.

According to the manufacturer, the product should not be used to cure nerve pain resulting from surgery, autoimmune disorders, tumors, infections, trauma, toxicity, or carpal tunnel syndrome. It is also advisable to consult a physician if you are under any medication or pre-existing medical conditions before taking the supplement. Each bottle has 60 capsules of the supplement, which should last you a month while taking two daily. If you find the product ineffective, you may request a refund within a year’s period, where the company will refund your entire purchase amount.

Nerve Rejuv


Unlike many other neuropathy supplements, Nerve Rejuv was created by approaching the condition from a nutrition viewpoint. Therefore, it contains a healthy list of vitamins and minerals to supplement the body, preventing neuropathy caused by nutritional imbalance. It is also anti-inflammatory to eradicate swelling and nerve pain.

Although the product is toxin-free, it is not advisable for minors, pregnant women, nursing mothers, and individuals under prescription medication before consulting a doctor. The product might cause minor side effects such as indigestion and headaches to some individuals. You can request a refund within 90 days of using the product if you see no satisfactory results. Send the bottles back to receive a full refund.

Nuturna Maximum Strength Neuropathy Support Formula


The Nuturna Max formula is not only a nerve remedying supplement but also a mood boost. According to customer reviews on Amazon, the product also promotes sleep and relieves nerve pains, especially in the legs. The formula consists of highly potent and proven nerve supplementing vitamins that some customers claim as their reason for purchasing the product.

Unlike most supplements, Nuturna Max can be consumed in higher or lower doses, depending on individual comfort levels. The manufacturer recommends beginning with a single capsule daily dosage for the first three days, then improving to two, three, and four capsules within three-day durations.

Nerve Renew


Unlike most supplements, Nerve Renew contains a type of vitamin B1, also known as benfotiamine, which penetrates cellular membranes. Benfotiamine is preferable to Thiamine, due to its higher absorption rate, according to the manufacturer. The product combines a variety of top-notch ingredients, including herbs and vitamins. Its cream formula consists of active ingredients, including benfotiamine, alpha-lipoic acid, and methylcobalamin. Other components include vitamin D, Vitamin B2, Vitamin B6, Oat Straw extract, Skullcap extract, Passionflower extract, and Feverfew extract.

Its active ingredients are one of the reasons why people choose to buy it. It also has a higher absorption rate than most other supplements on the market. The company also allows you to try the product with a money refund guarantee if it does not work. But one shortcoming is that the distributor only sells it; hence it might be costly to ship and hard to find anywhere else. Professor Don Kennedy’s formula is clinically and scientifically proven, according to the official distribution site. It has not contained any allergic triggers, although, like many other supplements, it is not advisable for nursing mothers and pregnant women.



Nervexol, another neuropathy supplementing formula, reduces nerve damage from the different vitamins, barks, flowers, and other herbs it contains. According to its maker, the supplement suppresses peripheral neuropathic symptoms such as chronic anxiety, numbness, weak nerves, mild stress, extreme pain, burning sensations, and tingling. Its ingredients include Calamarine, Thiamine, Benfotiamine, Vitamin D3, Alpha-lipoic acid, Corydalis, California poppy, and Passionflower.

Some of its acclaimed benefits include supporting better management of stress and anxiety, reducing inflammation, counteracting neuropathy pains, moderating blood sugar levels, empowering the body’s antioxidants, and preventing nerve degeneration. Although the product is made in an FDA-registered facility, it does not necessarily mean the FDA approves it. But if the manufacturer’s claim of sourcing its ingredients from nature is valid, then the product should not have any intoxicating effects. However, it lacks a standard dosage, although the package recommends consuming the 60 capsule bottles within a month.

Neuro Calm Pro


The toxic-free Neuro Calm Pro is Gerard Watson’s long-term research finding that includes all-natural ingredients. The manufacturer claims it can support hearing ability. The supplement repairs damaged nervous systems between the ear and the brain to re-enable hearing.

Its ingredients include Fenugreek extract, Fennel, L-Tyrosine, Saw palmetto, Damiana, Dong Quai, Mexican wild yam, Oat grass, Pacific kelp, motherwort, and hops extract. Additional ingredients include silicon dioxide, rice flour, gelatin, titanium dioxide, microcrystalline cellulose, magnesium stearate, and water.

On taking the supplement, you could enjoy improved hearing and a lesser risk of contracting tinnitus. The formula provides you with essential nutrients for ear cell nourishment. It also contains no intoxicants, meaning that it should not cause any severe side effects. However, it is not assured that you are safe from side effects as it reacts differently to different people. The product is also limited to its official site, meaning that it would be a hustle for international customers to acquire it.

Nuturna Clinical Strength Neuropathy 900


Like the other Nuturna products, customers also love this supplement for its B-Vitamins, especially the fat-soluble benfotiamine. According to some of its Amazon reviews, the product eliminates nerve pain within a few weeks of usage. It also improves mood and sleep quality.

According to the distributor, the product comes in 300g, 600g, and 900g daily dosage options of Alpha-Lipoic Acid.

Nonetheless, it also contains Vitamins B6, B12, C, D, and E, Magnesium, Curcumin, Organic Turmeric Root, Acetyl L-Carnitine, and Thiamine. These ingredients serve different nerve restoring functions to help eliminate pain so that you may once again do things you stopped doing at some point. It is also one of the best-selling supplements on Amazon, which could be due to its recommendation by some doctors and pharmacists.

Bonus Nerve Pain Guide #1: Neuropathy No More


This guide entails a supper dieting program that does not limit your food intake but helps you lose weight while fighting neuropathy. According to Jody, the program’s creator, her approach to solving neuropathy is based on the causes, which include inflammation and blood sugar levels.

Therefore, this guide focuses on the gut, which is responsible for controlling such body functions. The program guides you on how to take the right foods that will help recover your gut health by ensuring you have the right bacteria in your gut. It also includes readily available foods, how to prepare them, and the right amounts to consume each one of them. It also warns on the harmful ones and how to substitute them.

Bonus Nerve Pain Guide #2: Neuropathy Revolution


This guide takes you through a 7-step process to help eliminate your nerve pain. According to the creator, this guide is an all-natural, fast, and permanent solution exclusive to herbs and medication. Therefore, it is also a safe option. Its methods include increased lifestyles, increased exercise, improved nutrition, and better stress management techniques. It works by eliminating danger-posing toxins such as aflatoxins, fluoride, atrazine, and aspartame.

According to the creator, users of this guide might begin to notice improvements a day after following it. But to acquire a long-lasting solution, they might need to use the guide for about one or two months. It is also applicable to people of different ages, regardless of their neuropathic complications.

Our Ranking Process

The FDA is not authorized to test or approve supplements. Therefore, it might be challenging to distinguish those that work from the faulty ones. But by analyzing their ingredients, we could tell which ones are most effective. Also, those that have the most truthful information were prioritized in this ranking.

Scientifically Proven Facts

Most of the products on our list had scientific evidence backing the workability of their ingredients. By researching the individual components, you can find the same benefits mentioned in studies and other scientific sites.

Dosage Accuracy

The first step was to pick supplements that disclose their ingredients ratio, as they are more transparent. We also ensured that the amounts of individual components are enough to induce the benefits they claim. We also confirmed they are in quantities relative to other medical drugs.

Value over Price

When looking for the best products, you might have to spend a little higher than usual. But it does not necessarily mean that the best supplement is the most expensive. Our list of products considers those that bring you the best value at a reasonable cost.

Advertisement Transparency

Supplement companies are notorious for promising more than their products can deliver. You may then find yourself wasting time and cash on products that will hurt your health more than improving it. However, it is essential to note that supplements do not solely cure conditions, but help improve the situation or back up additional treatment options. We ensured the products on our list advertise the benefits that match the benefits of their ingredients.

Labeling Accuracy

When it comes to health matters, even the most minor mistake could lead to severe damages. Assuming you are suffering from a painful condition that requires you to strictly keep out certain ingredients, consuming a product without knowing its presence might put you on the death bed. Therefore, we choose only products that provide truthful labeling to understand what you are consuming.

Manufacturer Information

Any company would be proud to associate itself with a legit product that delivers. Therefore, we also checked how much the manufacturers disclose about themselves. This includes their reputation, other products, contact, and location. The supplements on our list come from recognized brands.

Customer Reviews

We ensured that we only included the products that deliver what they promise by considering what the public thinks about them. However, not all customer reviews are truthful. Therefore, we also weighed the customer reviews and compared them to the views of third parties to ascertain that they are effective.

Scientific Evidence for Neuropathy Supplements

It might be hard to tell if the manufacturers of these products are telling the truth or not. Besides, some of their products are still under trial; hence, it might be even harder to know if they work. But numerous scientific studies have been conducted to examine the effectiveness of individual ingredients on the symptoms. Here are some of them.

Alpha Lipoic Acid (ALA), an antioxidant ingredient present in most supplements, is said to relieve burning and stabbing discomforts that result from neuropathy. Various studies have tested and proven this, like the 2006 study that subjected some participants to 600mg, others to 1200mg, and the rest to 1800 mg of the component daily for several weeks. Those under actual medication showed lesser symptoms than those under placebos. But higher dosages of the element caused more side effects. They also noticed an increase in blood flow, especially in the upper arm, and an anti-inflammatory effect.

Acetyl-L-carnitine is found in numerous supplements, although the body also processes its own through the liver and kidneys. Besides suppressing neuropathy symptoms, the ingredient is sometimes consumed daily to boost both physical and cognitive energy.

B Vitamins are also common in neuropathy supplements. The most common ones include vitamins B6 and B12. A low level of these vitamins causes an imbalance in body functions. For example, a 2014 study found that the lack of sufficient Vitamin B12 and B6 in the body causes neuropathy symptoms, such as pain, especially in the feet. Therefore, supplementing the body with this Vitamin can reverse the symptoms.

Magnesium was tested for possible effects on neuropathy related to chemotherapy by the Foundation for Peripheral Neuropathy. The results implied that the presence of sufficient magnesium in chemotherapy patients matched a reduction in neuropathy symptoms. Yet a 2013 study on the same concluded that magnesium had no connection to neuropathy. Therefore, magnesium might positively impact, although they suggested further studies be conducted to verify the evidence.

Glutamine has been found to reduce or eliminate the level of neuropathy in chemotherapy patients. The human body has abundant glutamine as an amino acid. Besides neuropathy supplements and glutamine-specific supplements, the ingredients can also be found in peanuts, wheat, milk, egg whites, and corn, among other types of food. Glutamine suppresses neuropathy by minimizing tingling, muscle pain, numbness, and inflammation.

Glutathione is a common ingredient in many supplements related to neuropathy. This is due to the studies conducted that have proven its positive impact on multiple types of neuropathy, including diabetic and chemotherapy-related neuropathy. However, it might not be very effective when included in supplements due to its absorption issue. The body needs to break down most of it before consuming it.

Lifestyle changes have also been proven to harm neuropathy. This is why we recommend adopting new habits that will help drop the neuropathy-favoring factors for a quick recovery. According to multiple studies conducted, shingle vaccines regulate blood sugar levels, and physical activeness can help minimize the condition. Also, quitting some health deteriorating habits such as consuming toxins, including smoking, can promote treatment effectiveness.

Every patient has a different level of neuropathy, so consulting a medical professional for individual advice is essential. Neuropathy can be severe, much so that supplements cannot relieve its symptoms. In such cases, only a doctor may know the right treatments to help reduce it.

FAQs about Neuropathy Supplements

Q: What is neuropathy?

A: Neuropathy is a condition where a peripheral nerve is damaged or dysfunctional.

Q: What is peripheral neuropathy?

A: Peripheral neuropathy is a substitute for neuropathy. They both share a common meaning.

Q: What’s the difference between mononeuropathy and polyneuropathy?

A: Mono and Poly are added to neuropathy to show the number of nerves affected, where mono stands for a single one while poly stands for multiple nerves.

Q: What are the symptoms of neuropathy?

A: Some symptoms include pin-and-needle sensation, reduced touch sensitivity, numbness, pain, tingling and burning, and loss of muscle coordination.

Q: What causes neuropathy?

A: Damage to the nerves complicates the signals they send to your brains, causing the symptoms.

Q: How do doctors treat neuropathy?

A: A doctor may offer different types of treatments depending on individual conditions. They include medication, topical medication, physical therapy, and laser therapy. However, most of these treatments target symptoms rather than the root cause.

Q: How does neuropathy surgery work?

A: Also known as nerve decompression, the surgery involves pressure release from compression points on your nerves to eliminate symptoms. The surgery is performed on an outpatient basis.

Q: Why does neuropathy feel different in different people?

A: The nervous system sends signals from different body parts to the brain. It can be damaged differently, causing it not to send signals, send wrong signals, or send false signals when there should not be any.

Q: Does neuropathy hurt?

A: Yes, but the extent varies depending on the severity of the nerve damage. It could be mild, discomfort, or extreme.

Q: What nerves does neuropathy affect?

A: Nerve damage affects the following three primary nerves:

  • Motor nerves, which control body movements such as walking.
  • Sensory nerves, which control information transmission, such as touch.
  • Autonomic nerves control subconscious processes such as breathing.

Q: What are the most common causes of peripheral neuropathy?

A: Neuropathy can be caused by different nerve damage cases as follows:

  • Physical injury to the affected area, such as accidents.
  • Too much movement of the affected part over long periods.
  • Diabetes
  • Poor blood circulation to the nerves.
  • Smoking might lead to an increase in blood pressure.
  • Autoimmune diseases such as hormonal imbalance, cancer, and kidney and liver diseases.

Q: How do doctors diagnose neuropathy?

A: Doctors may check your medical history; conduct a physical and neurological exam to check for neuropathy. If your case is suspected to be genetic, then a genetic test might be performed. But even a fluid test could help diagnose the condition.

In some cases, they might test your nerve signal strength or conduct a neurodiagnostic skin biopsy.

Q: How do I prevent neuropathy?

A: Since diabetes is a common neuropathy cause, preventing it could be one way to prevent neuropathy. Nonetheless, a generally good lifestyle is the best way to avoid it. But you can consult your doctor for more specific advice.

Q: Is neuropathy genetic?

A: In the over 100 types of neuropathy, some such as the Charcot-Marie-Tooth disease, a nerve disorder, are considered genetic. However, neuropathy is mainly caused by lifestyle rather than genetics.

Q: Can pre-diabetes cause neuropathy?

A: Abnormally high blood sugar levels are a symptom of pre-diabetes which also exposes you to developing neuropathy. However, diabetes is the more common cause.

Q: How do neuropathy supplements work?

A: Some supplements address the root cause by eliminating inflammation and improving blood flow, while others provide the body with the components it needs to fight neuropathy.

Q: What’s the best neuropathy supplement?

A: The above list includes the best supplements, among which it is hard to pick one.

Top 12 Best Nerve Supplements in 2021 Final Words

Neuropathy is a common condition that is increasingly affecting people, especially the older generation. Taking the best nerve supplements is one way to stay healthy while minimizing your symptoms. However, even supplements need to be taken in the proper doses for maximum effectiveness. Therefore, read the instructions carefully to ensure that you make the most out of your chosen product.

People Also Read: Nerve Rejuv Reviews: Legit Nerve Health Support Ingredients?

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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